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New Cytotoxic Pregnane-type Steroid From The Stem Bark Of Aglaia Elliptica (Meliaceae)
New Cytotoxic Pregnane-type Steroid From The Stem Bark Of Aglaia Elliptica (Meliaceae)
Kindi Farabi, Desi Harneti, Nurlelasari, Rani Maharani, Ace Tatang Hidayat, Khalijah Awang, Unang Supratman, Yoshihito Shiono
Universitas Padjadjaran, Rec. Nat. Prod. 12:2 (2018) 121-127, ACG Publications, www.acgpubs.org/RNP © March-April 2018, EISSN:1307-6167, DOI: https://doi.org/10.25135/rnp.21.17.07.118
Bahasa Inggris
Universitas Padjadjaran, Rec. Nat. Prod. 12:2 (2018) 121-127, ACG Publications, www.acgpubs.org/RNP © March-April 2018, EISSN:1307-6167, DOI: https://doi.org/10.25135/rnp.21.17.07.118
Aglaia elliptica, Cytotoxic activity, Meliaceae, Pregnane-type steroid
Kindi Farabi, Desi Harneti, Nurlelasari, Rani Maharani, Ace Tatang Hidayat, Khalijah Awang, Unang Supratman, Yoshihito Shiono
Universitas Padjadjaran, Rec. Nat. Prod. 12:2 (2018) 121-127, ACG Publications, www.acgpubs.org/RNP © March-April 2018, EISSN:1307-6167, DOI: https://doi.org/10.25135/rnp.21.17.07.118
Bahasa Inggris
Universitas Padjadjaran, Rec. Nat. Prod. 12:2 (2018) 121-127, ACG Publications, www.acgpubs.org/RNP © March-April 2018, EISSN:1307-6167, DOI: https://doi.org/10.25135/rnp.21.17.07.118
Aglaia elliptica, Cytotoxic activity, Meliaceae, Pregnane-type steroid
A new pregnane-type steroid, 2a-hydroxy-3a-methoxy-5a-pregnane (1), together with three known dammarane-type triterpenoid, 3ß-acetyl-20S,24S-epoxy-25-hydroxydammarane (2), 20S,24S-epoxy-3a,25dihydroxydammarane (3), and eichlerianic acid (4) have been isolated from the stem bark of Aglaia elliptica. The structures were determined by spectroscopic methods including the 2D-NMR techniques. Compound 1-4 showed moderate cytotoxic activity against P-388 murine leukemia cells.
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