Abstrak 
Cytotoxicity and Structure Activity Relationship of Dammarane-Type Triterpenoids from the Bark of Aglaia elliptica against P-388 Murine Leukemia Cells
Ace Tatang Hidayat, Kindi Farabi, Desi Harneti, Rani Maharani, Darwati, Nurlelasari, Tri Mayanti, Arlette Suzy Setiawan, Unang Supratman, Yoshihito Shiono
Universitas Padjadjaran, Natural Product Sciences 23(4) : 291-298 (2017), https://doi.org/10.20307/nps.2017.23.4.291
Bahasa Inggris
Universitas Padjadjaran, Natural Product Sciences 23(4) : 291-298 (2017), https://doi.org/10.20307/nps.2017.23.4.291
Aglaia elliptica, Dammarane-type Triterpenoids, Meliaceae, P-388 murine leukimia cell
Six dammarane-type triterpenoids, dammar-24-en-3ß-ol (1), 3ß-epicabraleahydroxy lactone (2), (E)25-hydroperoxydammar-23-en-3ß,20-diol (3), dammar-24-en-3ß,20-diol (4), 3ß-acetyl-20S,24S-epoxy-25-hydroxydammarane (5), and 3ß-epiocotillol (6) were isolated from the methanolic extract of the bark of Aglaia elliptica. The chemical structure were identified on the basis of spectroscopic evidence and by comparison with those spectra previously reported. Compounds 1 – 6 were isolated first time from this plant. Compounds 1 – 6, along with a known synthetic analog, cabraleone (7) were evaluated their cytotoxic activity against P-388 murine leukimia cells in vitro. Among those compounds 3ß-acetyl-20S,24S-epoxy-25-hydroxydammarane (5) showed strongest cytotoxic activity with IC 50 value of 8.02 ± 0.06 µM.