Pustaka Ilmiah Universitas Padjadjaran

Abstrak

Antihypertensive Activities Instant Granul of Combination Extract Roselle Flower Petals (Hibiscus sabdariffaL.), Chayote Fruit (Sechium edule (Jacq.) Sw.) and Aloe Vera Leaves (Aloe Vera L.) In White Male Rats

Hypertension is a condition where the systole blood pressure greater than 140 mmHg and diastole blood pressure greater than 90 mmHg. The previous study showed that the combination of roselle flower petal Hibiscus sabdariffa L.), chayote fruit (Sechium edule (Jacq.) Sw.), aloe vera leaf (Aloe vera L.) extracts can reduced high blood pressure better than its single herb extract. The purpose of this research is to determine the optimal dose of instant granules from a combination of extracts of roselle flower petals (Hibiscus sabdariffa L.), chayote fruit (Sechium edule (Jacq.) Sw.), aloe vera leaf (Aloe vera L.) on white male rats Rattus norvegicus Sprague Dawley that induced with adrenaline 1.2 mg/kg BW intraperitoneally using Non-Invasive Blood Pressure method. The instant granule suspension preparation is administered orally at doses 0.5 g/200 g BW, 0.75 g/200 g BW and 1 g/200 g BW. The results showed that at the significance level of 0.05, all the instant granule doses tested have an activity of reduction of systolic and diastolic blood pressure, respectively 30.27% and 31.86%, 21.77% and 21.27%, 18.39%, and 23.05%.