Abstrak 
Cytotoxic Steroids From The Stem Bark Of Chisocheton Cumingianus (Steroid Dengan Aktivitas Sitotoksik Dari Kulit Batang Chisocheton Cumingianus (Meliaceae))
Dewa Gede Katja, Kindi Farabi, Nurlelasari, Desi Harneti, Rani Maharani, Euis Julaeha, Ace Tatang Hidayat, Tri Mayanti, Unang Supratman
Universitas Padjadjaran, Molekul, Vol. 12. No. 1, Mei 2017 : 1 – 7, ISSN 1907-9761, doi: 10.20884/1.jm.2016.11.2.242
Bahasa Indonesia, Bahasa Inggris
Universitas Padjadjaran, Molekul, Vol. 12. No. 1, Mei 2017 : 1 – 7, ISSN 1907-9761, doi: 10.20884/1.jm.2016.11.2.242
C. cumingianus, Chisocheton, Cytotoxic activity, Meliaceae, sifat sitotoksik, steroids
Three cytotoxic steroids, stigmasterol (1), stigmast-5-en-3?-ol (2) and ?-sitosterol-3-O-acetate (3) were isolated from the stem bark of Chisocheton cumingianus. The chemical structures of those compounds were identified based on spectroscopic data and by comparison with those data previously reported. All of the compounds isolated were evaluated for their cytotoxic effects against P-388 murine leukemia cells in vitro. Compounds 1-3 showed cytotoxicity activity against P-388 murine leukemia cells with IC50 values of 12.4, 60.8, and ? 100 ?g/mL, respectively.
Tiga senyawa steroid yang beraktivitas sitotoksik, stigmasterol (1), stigmast-5-en-3?-ol (2) dan ?-sitosterol-3-O-acetate (3) telah diisolasi dari kulit batang Chisocheton cumingianus. Struktur kimia senyawa tersebut diidentifikasi berdasarkan data-data spektroskopi dan perbandingan dengan data spektra yang diperoleh sebelumnya. Semua senyawa hasil isolasi dievaluasi sifat sitotoksiknya terhadap sel murine leukimia P-399 secara in vitro. Senyawa 1-3 menunjukkan aktivitas sitotoksik terhadap sel murine leukimia P-388 dengan nilai IC 50 beturut-turut 12,4; 60,8 dan ? 100 ?g/mL.