Abstrak 
Senyawa Yang Beraktivitas Antifertilitas Dari Kulit Batang Alstonia Scholaris (Apocynaceae)
Euis Julaeha, Tri Mayanti, Rani Maharani, Desi Harneti Putri Huspa, Unang Supratma
Universitas Padjadjaran, Bulletin Of The Indonesian Society Of Natural Products Chemistry Vol. 11 No. 2 July-December 2011, ISSN 1411-9268
Bahasa Indonesia, Bahasa Inggris
Universitas Padjadjaran, Bulletin Of The Indonesian Society Of Natural Products Chemistry Vol. 11 No. 2 July-December 2011, ISSN 1411-9268
Alstonia scholaris, Antifertilitas, antifertility activity, cytosterol-3 β-D-galactose, secopregnane., seeo-pregnana, sitosterol-3β-Dsgalaktosa, β-amirin, β-amyrin
Tiga senyawa yang bersifat antifertilitas, yaitu β-amirin (1), seeo-pregnana (2) dan sitosterol-3β-D« galaktosa (3), telah diisolasi dari kulit batang Alstonia seholaris (Apocynaceae). Struktur kimia ketiga senyawa tersebut diidentifikasi berdasarkan data spektroskopi dan perbandingan data spektrum dengan yang telah dilaporkan sebelumnya. Senyawa 1-3 dievaluasi sifat antifertilitasnya terhadap spermatozoa manusia, dan pada konsentrasi 12,5 nglmL menurunkan motilitas dan viabilitas spermatozoa manusia berturut-turut sebesar 65%, 68%, 119%, dan 41%, 72%, 60%, serta meningkatkan abnormalitas berturut-turut sebesar 112%, 162%, and 56%.
Three antifertility compounds, namely β -amyrin (1), seco-pregnane (2) and cytosterol- 3β –D-galactose (3), were isolated from the bark of Alstonia scholaris (Apocynaceae). The chemical structures of these compounds were identified by spectroscopic data and by comparison with those previously reported. Compounds 1-3 were evaluated for their antifertility effects against human spermatozoas, and at concentrations of 12.5 ng/ml, decreased their motilities by 65%, 65%, and 119%, and viabilities by 41%, 72%, and 60%, respectively, and increased their abnormalities by 112%, 162%, and 56%, respectively.