Abstrak 
Insecticidal Compounds from Indonesian Plants
Unang Supratman, Tri Mayanti, Tali Herlina,Euis Julaeha, Nurlelasari, Desi Harneti, Hideo Hayashi
Universitas Padjadjaran, Prosiding Seminar Kimia Bersama ITB-UKM Keenam "Perkembangan Terkini Ilmu Kimia Yang Berlandaskan Kajian Sumber Alam", Denpasar, 17-18 Mei 2005 Bali-Indonesia, ISBN: 979-9299-16-0, Homepage : https://www.chem.itb.ac.id/jschem
Bahasa Inggris
Universitas Padjadjaran, Prosiding Seminar Kimia Bersama ITB-UKM Keenam "Perkembangan Terkini Ilmu Kimia Yang Berlandaskan Kajian Sumber Alam", Denpasar, 17-18 Mei 2005 Bali-Indonesia, ISBN: 979-9299-16-0, Homepage : https://www.chem.itb.ac.id/jschem
Bryophyllin, Bufadienolide, Crassulaceae, insecticidal activity, Kalanchoe
During the random screening of Indonesian plants for insecticidal compounds. Kalanchoe pinnata and K. daigrernontiana were found to show a potent insecticidal activity against the third larvae of silkworm (Bombyx mori). K. pinnata leaves were shown to produce a new insecticidal bufadienolide. bryophyllin C and a known bufadienolide. bryopltyllin A. together with an inactive bersaldegenin-3-acetate. meanwhile a new insecticidal bufadienolide. methyl daigremonate and three known bufadienolides. bersaldegenin-l,3,5-orthoacetate. daigremontianin. and bersaldegenin-l-acetate were isolated from the leaves of K. daigremontiana In order to clarify the functional groups responsible for the insecticidal activity. two a-pyrone opening derivatives were prepared and their insecticidal activity was compared with those of other bufadienolides. As a result, both the orthoacetate and a-pyrone moiety seemed to be essential structural elements for exhibiting a potent insecticidal activity. In addition, oxygenated substituents at C-11 and C-12 in ring C enhanced the insecticidal activity.