Abstrak 
Antifertility Compounds Isolated from Leaves of Senggugu (Clerodendron serratum L.Moon)
Euis Julaeha, Supriyatna, Anas Subarnas, Unang Supratman, Dikdik Kurnia, Hideo Hayashi
Universitas Padjadjaran, Proceeding of The International Seminar on Chemistry 2008 (pp. 604-609) Jatinangor, 30-31 October 2008, ISBN 978-979-18962-0-7
Bahasa Inggris
Universitas Padjadjaran, Proceeding of The International Seminar on Chemistry 2008 (pp. 604-609) Jatinangor, 30-31 October 2008, ISBN 978-979-18962-0-7
antifertility, Clerodendron serratum, Rattus novergicus, Senggugu
Senggugu (Clerodendron serratum L. Moon) is a traditional plant from Asia and reported to possess an antifertility in male rat, but no information concerning the chemical constituent of the active compound. As a part of our continuing search for novel antifertility compound from Indonesian medicinal plants, the methanolic extract of the leaves of Senggugu showed a significant antifertility against spermatozoa of white rat (Rattus novergicus) in vitro at a concentration of 12.5 ng/L. The aqueous extract was partitioned successively by n-hexane, ethyl acetate and methanol. The ethyl acetate showed antifertility against spermatozoa of white rat. By using the antifertility activity to follow separations, the ethyl acetate fraction was separated by combination of column chromatography on Kieselgel 60 to yield three active compounds (1-3). The chemical structure of these compounds were determined based on spectroscopic analysis and comparison with those related data previously reported. Antifertility of those compounds (1-3) showed motility of 51%, 24.7%, and 36.4%, respectively, viability of 82.2%, 92.6%, and 82.2%, respectively, and abnormality of 71.2%, 55.4%, and 43.1%, respectively. In this presentation the isolation, structure determination, and antifertility activity against spermatozoa of white rat (Rattus novergicus) of those compounds will be described.