Pustaka Ilmiah Universitas Padjadjaran

Abstrak

Iron Overload Reduces Cholestrol and Triglyceride Serum of Mice

Introduction: Most of the case of patient with hemoglobin disorder genes need routine blood transfusion throughout their life. It leads to increase iron accumulation with liver as the main organ for iron storage. Liver is the main organ for metabolic process, including triglyceride and cholesterol. However, correlation between metabolism of triglyceride and cholesterol, and iron overload condition is remain uncertain. The purpose of this study was to investigate the effect of iron overload to triglyceride and cholesterol level in the serum of mice. Material & Method: Three groups of mice were divided by the dose of iron dextran (0,0.1 and 0.3 mg/mouse). Iron dextran was injected intraperitoneally. After 14 days of treatment, liver histology and serum triglyceride and total cholesterol were examined. Result & Discussion: Liver weight was higher in iron dextran injected mice proportional with dose injection. The liver histology showed normal tissue and slightly inflammation condition with no fibrosis sign. Total cholesterol and triglyceride serum were lower 21,46% and 27,68% respectively in mice injected with 0.3 mg/mouse of iron dextran compare to control group. Conclusion: Iron dextran injection in 0.3 mg/mice of dose reduces cholesterol and triglyceride serum without alteration liver morphology.