Pustaka Ilmiah Universitas Padjadjaran

Abstrak

Antibacterial Terpenoid from The Bark of Lansium domesticum Corr cv. Kokossan (Meliaceae)

In the course of our continuing search of novel active compounds from Indonesian plants, the methanolic extract of bark of L. domesticum cv kokossan showed significant antibacterial activity against B. cereus and E. coli. The methanolic extract of the bark of L. domesticum cv kokossan was concentrated and extracted with ethyl acetate. The ethyl acetate extract exhibited an antibacterial activity with inhibit zone respectively 12.5 and 14 mm against B. cereus and E. coli. The ethyl acetate fraction was separated by combination of column chromatography on Kieselgel 60 to afford an antibacterial compound as white crystal with melting point 166-168oC. Based on UV, IR, H1-NMR, C13-NMR and 2DNMR spectroscopic evidences and comparison with previously data reported indicated that isolated compound as terpenoid group. An antibacterial compound showed antibacterial activity with inhibit zone 10 mm at concentration of 1000 ppm against E. coli.