Pustaka Ilmiah Universitas Padjadjaran

Abstrak

The Development of PC-Based BME-ITB Beads to Evaluate Antibiotic Release Kinetics from Bone Cement (A Preliminary Report)

Inadequate treatment of the acute phase of hematogenous osteomyelitis (bone infection) allows the local pathological process either to persist and become chronic or to become relatively quiescent for a time, only to recur at a later date. Both the persistent chronic form and the recurrent chronic form of bone infection are exceedingly difficult to eradicate. Chronic bone infection can seldom be completely eradicated until all the infected dead bone has separated, or sequestrated, and has either been extruded spontaneously through a sinus tract or been removed surgically (sequesterectomy). Antibacterial therapy is required both systemically and locally. Antibiotic-loaded bone cements have been used for a long time in clinical orthopaedics, despite the fact that it is still in the phase of trying to understand how and why these bone cements work. New antimicrobial agents are therefore needed in considering cost effective and high effective in killing the microorganisms. We proposed the usage of BME-ITB Beads by definition is an antibiotic loaded beads in home-made, mixtures antibiotic (fosfomycin sodium) with the artificial resin polymethylmethacrylate (PMMA). The purpose of the study is to [1]. Evaluate currently used home-made antibiotic loaded beads and compare their antimicrobial efficiency with the efficiency of an existing (patented) product; [2]. Develop an improved concept for the local production by orthopaedic surgeons of antibiotic-loaded beads for the treatment of orthopaedic infections. First, different orthopaedic surgeons are requested to make an overview of different local concepts developed to prepare antibiotic-loaded beads. Based on this overview, five concepts will be selected for further research and each of the participating surgeons will be asked to submit an extensive protocol of their concept. A first evaluation will include a laboratory study on the antibiotic release kinetics, as well as a scanning electron miscroscopic evaluation of the porosity and a quantification of the porosity mercury-intrusion porosimetry. Personal Computer (PC) is used to simulate the porosity of the beads. This project is expected to yield application of the new concept in developing countries around the globe, and has as a rationale that we feel all orthopaedic patients worldwide are entitled to the same effective health care.