Pustaka Ilmiah Universitas Padjadjaran

Abstrak

The Influence Of Oleic Acid Into Diffusion Rate Of Piroxicam In Aqupec Hv-505 Gel Base

The purpose of this research was to find out the influence of oleic acid as enhancer in piroxicam gel. An in vitro research about the effect of oleic acid in diffusion of piroxicam gel in aqupec 505 HV base had been done. Piroxicam is an anti-inflammatory agent for treatment of arthritis rheumatoid. Piroxicam gels was made in aqupec 505 HV using oleic acid of 0, 1, 3, 5% in the formula F0, F1, F2, and F3 respectively. The results of stability test including organoleptic, pH, measuring of viscosity and piroxicam homogeneity showed that piroxicam gel fulfilled the requirements of a pharmaceutical dosage form. The optimum increased of diffusion rate was shown in F2, with addition of 3% oleic acid.