Abstrak 
Development Of Patch Ketoprofen Using Chitosan As Polymer Matrix
Soraya Ratnawulan Mita, Driyanti Rahayu, Insan Sunan Kurniawansyah, Anis Yohana Chaerunisaa, Handi Purnama
Universitas Padjadjaran, Journal Of Pharmaceutical Sciences And Research Vol. 10(1) 2018, 8-15, ISSN:0975-1459, www.jprs.pharmainfo.in
Bahasa Inggris
Universitas Padjadjaran, Journal Of Pharmaceutical Sciences And Research Vol. 10(1) 2018, 8-15, ISSN:0975-1459, www.jprs.pharmainfo.in
chitosan, ketoprofen, Transdermal patch
Patch is a transdermal dosage form that has increasing number of applications for its simplicity with controlled release profile of drug. The ability to provide controlled release manner of drug is developed by the use of polymer as the matrix. In this research, patch of ketoprofen were formulated using various concentrations of chitosan as matrix. Preparation of the transdermal patch were conducted by using solvent evaporation method. Characterization of patch were included physical characteristic, homogeneity, drug assay, drug permeation and stability study. Permeation test were performed in vitro by using Franz diffusion cells with shed snake’s skin of Phyton reticulatus as diffusion membrane for 24 hours. The result showed that Chitosan is a potential polymer to be used as matrix for patches since it was stable and gave peel off ability. Permeability test showed that a decrease in permeation of ketoprofen was in line with the increase of chitosan as matrix. Formula containing chitosan 1% and tween 80 0,3% as permeation enhancer gave the highest permeation number as much as 99,15%.